About FedImpute
AfriGen-D FedImpute is an African-led, African-hosted platform for genotype imputation. Researchers upload VCF files, discover reference panels across federated nodes, and run imputation workflows -- all through GA4GH standard APIs.
The platform is built for federation: every node exposes the same GA4GH services (WES, DRS, Data Connect, Passport), so a single submission can run against multiple nodes and panels. Data stays on African infrastructure under POPIA, and access is governed by Passport visas rather than per-service accounts.
Standards Compliance
The platform is built on open standards from the Global Alliance for Genomics and Health (GA4GH) to ensure interoperability, security, and reproducibility across all connected services.
Participating Institutions
AfriGen-D FedImpute is built and operated in partnership with:
Acknowledgements
We are using a lot of tools that we are listing here.
Project and Data Contributors
We sincerely thank all study investigators who contributed their valuable data to the reference panel. Their generosity and willingness to share these data, now accessible through this service, have been instrumental in its development and success.
We recognize and appreciate the significant contributions of the H3ABioNet Refimpute project members in generating the final reference panel and associated pipelines.
The project is governed by the University of Cape Town Human Research Ethics Committee, Approval No: HREC R043/2018.
Finally, we extend our profound gratitude to the participants who generously provided biological samples.