About FedImpute

AfriGen-D FedImpute is an African-led, African-hosted platform for genotype imputation. Researchers upload VCF files, discover reference panels across federated nodes, and run imputation workflows -- all through GA4GH standard APIs.

The platform is built for federation: every node exposes the same GA4GH services (WES, DRS, Data Connect, Passport), so a single submission can run against multiple nodes and panels. Data stays on African infrastructure under POPIA, and access is governed by Passport visas rather than per-service accounts.

Standards Compliance

The platform is built on open standards from the Global Alliance for Genomics and Health (GA4GH) to ensure interoperability, security, and reproducibility across all connected services.

GA4GH DRS v1.5.0GA4GH WES v1.1.0GA4GH Passport/VisaGA4GH Service InfoGA4GH Data Connect v1.0.0GA4GH TRS v2RO-Crate

Participating Institutions

AfriGen-D FedImpute is built and operated in partnership with:

H3Africa Consortium

The Human Heredity and Health in Africa initiative, advancing genomic research across the African continent with population-specific reference panels.

University of Cape Town / ILIFU

AfriGen-D is hosted at the University of Cape Town on the ILIFU research cloud, a shared data-intensive research platform for African institutions.